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Melanin Transfer Inhibitors

Pigment is spread by cells called melanocytes, moving it into the surrounding skin.

This process is controlled by an opening or door on the cell, which is controlled by a “key” known as a protease-activated receptor (PAR-2).

By blocking this receptor, less pigment can be spread, causing an improvement in facial tone. 

These ingredients are called PAR-2 blockers.

Visible improvement takes 8-16 weeks.

Examples include


Soy (used in many skincare products).

Bowman-Birk protease inhibitor (BBI).

Peptides such as trypsin.

PAR-2 inhibitors work best combined with retinoids and tyrosine inhibitors.

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